So what do you do if you have just a huge pimple? So first of all don't freak out. Second of all do not try to pop it and I know it's gonna be very hard to follow that direction. But please don't, because you will just make it worse. What are things you can do? You can definitely use hot compresses. Put some hot water on a washcloth and put it on the pimple a couple times or 3 times a day for 5 minutes. You can also use a spot treatment and my favorite are sulfur based spot treatments. These are available from many different brands. Just make sure you're not allergic to sulfa before you use them. You can also do the home remedy of honey. Just put some raw unprocessed honey on the pimple and let it dry for about half an hour. I don't recommend using toothpaste. I know that there's lots of stuff about that on the internet, but I do think it irritates the skin and even can burn the skin around the pimple. And lastly this is the right time to make friends with a Dermatologist who can get you in that same day for a Cortisone injection. A Cortisone injection is an anti-inflammatory right into the heart of the big pimple that will help it come down within 24 hours.