Treatment options for late stage skin cancer will depend on the type of skin cancer you have.
Malignant melanoma with metastases is still very difficult to treat. There's an enormous amount of research going into finding a better treatment for malignant melanoma, but there's still a lot that needs to be done. Currently, melanoma with metastasis is one of the deadliest cancers that can affect the human body.
The mortality rate ranges anywhere from 20 to 50 percent within two years of diagnosis. Prognosis for late stage squamous cell and basal cell tends to be significantly better. Basal cells, even if they're large, rarely metastasize, so local treatment is sufficient, either with excision, or with excision and radiation. Squamous cell carcinomas do not metastasize until very late in the game. So even if the lesion is large, chances are local excision with radiation will be able to cure your symptoms.