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Prostaglandin E1 & Erectile Dysfunction

Learn about prostaglandin E1, a drug used to treat erectile dysfunction, in this Howcast video.


Prostaglandin E1 is a compound that's produced by your body naturally. It actually allows for dilation of blood vessels. And it is incorporated into various treatments for erectile dysfunction. One particular treatment that utilizes prostaglandin E1 is for penile injection therapy. This type of therapy uses a combination of several products that act as vasodilators. These products can include things like prostaglandin E1, papaverine, phentolamine, and various other products that have direct effects on the blood vessels within the penile tissues, that causes expansion of those blood vessels, and facilitates an erection.

Prostaglandin E1 also comes in a different form, a pill form that is used as a urethral suppository. What that means is that this pill is inserted directly into the urethra, the opening that you urinate through. And that pill then gets absorbed by the lining of the urethra, and gets distributed to the penile tissues.

The protaglandin E1 then has the direct effect on the blood vessels within the penile tissues, to cause dilation and expansion of the penile tissues, and thereby, facilitating erections. But prostaglandin E1 also, when used, can cause some pain with erections, due to the dilation effects, and due to stimulation of some of the pain nerves within the penile tissues.

Although it is an effective agent and is incorporated in several different treatments for erectile dysfunction, one of the potential side effects may be some pain associated with it.

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